Single-cell RNA sequencing unravels T cell exhaustion underlying the chronicity of chromoblastomycosis

IntroductionChromoblastomycosis (CBM) is a chronic, neglected tropical fungal infection. Its immunopathogenesis, particularly the mechanism underlying its chronicity, remains poorly understood.MethodsWe performed single-cell RNA sequencing (scRNA-seq) on lesional skin from a CBM patient, followed by...

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Detalhes bibliográficos

Principais autores:	Kexin Lei, Jie Tian, Lu Zhang, Zhuoqing Gong, Wenjie Liu, Zhe Wan, Yang Wang, Ruoyu Li, Bilin Dong, Xiaowen Wang
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-04-01
coleção:	Frontiers in Immunology
Assuntos:	chromoblastomycosis chronic fungal infection LAG-3 PD-1 single-cell RNA sequencing T cell exhaustion
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1784450/full
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