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PEGylation Effects on Amphiphilic Platinum(IV) Complexes: Influence on Uptake, Activation, and Cytotoxicity

<b>Background/Objectives:</b> The utilization of amphiphilic Pt(IV) complexes as prodrugs offers a promising strategy to revolutionize Pt-based cancer therapy by enhancing drug delivery and activation. While PEGylation is widely used to optimize drug properties, its impact on the biological behavior...

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Principais autores: Arpit Sharma, Md Al Amin, Man B. Kshetri, Suha Alqarni, Wjdan Jogadi, Jordan Solmen, Zexin Lin, Shirin Akter, Yao-Rong Zheng
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2025-03-01
Serier:Pharmaceutics
Fag:
platinum(IV) prodrugs
PEGylation
cisplatin
mitochondria
Online adgang:https://www.mdpi.com/1999-4923/17/4/440
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