Ras conformational switching: simulating nucleotide-dependent conformational transitions with accelerated molecular dynamics.
Ras mediates signaling pathways controlling cell proliferation and development by cycling between GTP- and GDP-bound active and inactive conformational states. Understanding the complete reaction path of this conformational change and its intermediary structures is critical to understanding Ras sign...
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| Главные авторы: | , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
Public Library of Science (PLoS)
2009-03-01
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| Серии: | PLoS Computational Biology |
| Online-ссылка: | https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000325&type=printable |
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