Long-read sequencing identifies aberrant fragmentation patterns linked to elevated cell-free DNA levels in cancer

Abstract Background Altered circulating cell-free DNA (cfDNA) fragmentation patterns serve as cancer biomarkers, yet standard short-read sequencing fails to capture the full fragment-length spectrum. Although cancer patients often exhibit elevated cfDNA, the relationship between high cfDNA concentra...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Benjamin P. Berman, Sarah A. Erdman, Christina Wheeler, Justin Cayford, Jean-Valery Turatsinze, Maria Ouzounova, Marie Piecyk, Marielle Herzog, Léa Payen-Gay, Thomas Walter, Theresa K. Kelly
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2026-04-01
Schriftenreihe:	Genome Biology
Online-Zugang:	https://doi.org/10.1186/s13059-026-04060-8
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