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Clinical Validation of the Somatic FANCD2 Mutation (c.2022-5C>T) as a Novel Molecular Biomarker for Early Disease Progression in Chronic Myeloid Leukemia: A Case–Control Study

<b>Background:</b> Chronic myeloid leukemia (CML) results from chromosomal translocation t(9;22) leading to the formation of the BCR-ABL fusion oncogene. CML has three stages: the chronic phase (CP), the accelerated phase (AP), and the blast crisis (BC). Tyrosine kinase inhibitors (TKIs) have revolu...

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Principais autores: Nawaf Alanazi, Abdulaziz Siyal, Sulman Basit, Masood Shammas, Sarah Al-Mukhaylid, Aamer Aleem, Amer Mahmood, Zafar Iqbal
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2024-07-01
Series:Hematology Reports
Assuntos:
chronic myeloid leukemia
CML progression
poor survival
genomic instability
DNA repair
FANCD2
Acceso en liña:https://www.mdpi.com/2038-8330/16/3/45
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