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Investigation of tryptophan to kynurenine degradation in response to interferon-γ in melanoma cell lines

Background and aim: Melanoma is a fatal form of skin cancer that carries a grave prognosis if the cancer cells spread and form metastases. The Kynurenine (Kyn) pathway is activated by the enzyme indoleamine 2,3-dioxygenase 1 (IDO-1) and has been shown to have a role in tumour progression. We have pr...

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Autors principals: Helena Tassidis, Skaidre Jankovskaja, Kassem Awad, Lars Ohlsson, Anette Gjörloff Wingren, Anna Gustafsson
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2024-03-01
Col·lecció:Biochemistry and Biophysics Reports
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S2405580823001930
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