TIMP2 promotes AKI‐CKD transition by inducing tubular maladaptive repair and cell senescence via targeting Wnt/β‐catenin signalling

Abstract Background Acute kidney injury (AKI) frequently progresses to chronic kidney disease (CKD), but the underlying mechanisms of this transition remain unclear. While TIMP2 is a known biomarker for AKI, its direct pathogenic role in the AKI‐CKD transition has not been fully elucidated. Methods...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Dongxue Xu, Haichuan Yu, Jingjing Pang, Xiaoyu Zhang, Jun Jiang, Yiming Li, Zhiyong Peng
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Wiley 2026-02-01
Schriftenreihe:	Clinical and Translational Medicine
Schlagworte:	AKI CKD TIMP2
Online-Zugang:	https://doi.org/10.1002/ctm2.70605
Tags:	Tag hinzufügen Keine Tags, Fügen Sie das erste Tag hinzu!