Dysregulated expression of miR-140 and miR-122 compromised microglial chemotaxis and led to reduced restriction of AD pathology

Abstract Background Deposition of amyloid β, which is produced by amyloidogenic cleavage of APP by β- and γ-secretase, is one of the primary hallmarks of AD pathology. APP can also be processed by α- and γ-secretase sequentially, to generate sAPPα, which has been shown to be neuroprotective by promo...

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Principais autores:	Chao Song, Shufang Li, Yingren Mai, Linpeng Li, Guoku Dai, Yuan Zhou, Xiaosheng Liang, Olivia Meilan Zou, Ya Wang, Libing Zhou, Jun Liu, Yi Zou
Format:	Artigo
Sprog:	Inglês
Udgivet:	BMC 2024-07-01
Serier:	Journal of Neuroinflammation
Fag:	Alzheimer’s disease Microglial Neuroinflammation
Online adgang:	https://doi.org/10.1186/s12974-024-03162-z
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