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FMRP regulates neuronal RNA granules containing stalled ribosomes, not where ribosomes stall

Local protein synthesis is a crucial process that maintains local proteostasis in neurons. A large percentage of mRNAs translated in developing neurons are associated with stalled ribosomes. FMRP, the protein lost in Fragile X syndrome, is highly enriched in RNA granules that contain stalled ribosom...

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Main Authors: Jewel T-Y Li, Mehdi Amiri, Senthilkumar Kailasam, Lily Drever, Jingyu Sun, Laura Bohorquez, Nahum Sonenberg, Joaquin Ortega, Wayne S Sossin
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications Ltd 2026-07-01
Series:eLife
Subjects:
stalled ribosome
FMRP
RNA granule
ribosome-protected fragment
ribopuromycylation
RNA binding protein
Online Access:https://elifesciences.org/articles/106692
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