Rational Designed Hybrid Peptides Show up to a 6-Fold Increase in Antimicrobial Activity and Demonstrate Different Ultrastructural Changes as the Parental Peptides Measured by BioSAXS

Antimicrobial peptides (AMPs) are a promising class of compounds being developed against multi-drug resistant bacteria. Hybridization has been reported to increase antimicrobial activity. Here, two proline-rich peptides (consP1: VRKPPYLPRPRPRPL-CONH2 and Bac5-v291: RWRRPIRRRPIRPPFWR-CONH2) were comb...

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主要な著者:	Kai Hilpert, Jurnorain Gani, Christoph Rumancev, Nathan Simpson, Paula Matilde Lopez-Perez, Vasil M. Garamus, Andreas Robert von Gundlach, Petar Markov, Marco Scocchi, Ralf Mikut, Axel Rosenhahn
フォーマット:	Artigo
言語:	Inglês
出版事項:	Frontiers Media S.A. 2021-12-01
シリーズ:	Frontiers in Pharmacology
主題:	antimicrobial peptide hybrid peptide BioSAXS multi-drug resistance antimicrobial compound mode of action
オンライン･アクセス:	https://www.frontiersin.org/articles/10.3389/fphar.2021.769739/full
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