Dynamic changes in peripheral blood lymphocyte subsets predict the efficacy and prognosis of immune checkpoint inhibitors in metastatic osteosarcoma

BackgroundOsteosarcoma (OSA) remains the most common primary malignant bone tumor in children and adolescents, with a poor prognosis for metastatic disease. While immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment, their efficacy in metastatic OSA is limited and highly variable...

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Hlavní autoři:	Longqing Li, Jinlei Liu, Yuan Zhao, Songtao Pang, Bin Zhang, Jia Wen, Yongkui Liu, Yi Zhang, Yan Zhang, Jiazhen Li, Nan Zhou, Xinchang Lu
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2026-05-01
Edice:	Frontiers in Immunology
Témata:	biomarkers immune checkpoint inhibitors metastatic osteosarcoma peripheral blood lymphocyte subsets
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1766639/full
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