Sororin locks the DNA-exit gate of cohesin to preserve sister-chromatid cohesion
Abstract The cohesin complex mediates sister-chromatid cohesion by topologically entrapping DNA within an SMC1-SMC3-RAD21 ring, yet how Sororin preserves cohesion beyond its known role of antagonizing Pds5 binding to the release factor Wapl has remained unclear. Here, we show that the extreme C-term...
Gorde:
| Egile Nagusiak: | , , , , , , , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
Nature Portfolio
2026-03-01
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| Saila: | Nature Communications |
| Sarrera elektronikoa: | https://doi.org/10.1038/s41467-026-70484-2 |
| Etiketak: |
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