Simple two-step synthesis of 2,4-disubstituted pyrroles and 3,5-disubstituted pyrrole-2-carbonitriles from enones

The cyclocondensation of enones with aminoacetonitrile furnishes 3,4-dihydro-2H-pyrrole-2-carbonitriles which can be readily converted to 2,4-disubstituted pyrroles by microwave-induced dehydrocyanation. Alternatively, oxidation of the intermediates produces 3,5-disubstituted pyrrole-2-carbonitriles...

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Detalhes bibliográficos

Principais autores:	Murat Kucukdisli, Dorota Ferenc, Marcel Heinz, Christine Wiebe, Till Opatz
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Beilstein-Institut 2014-02-01
coleção:	Beilstein Journal of Organic Chemistry
Assuntos:	α-aminonitriles cyclization heterocycles microwave-assisted synthesis pyrroles
Acesso em linha:	https://doi.org/10.3762/bjoc.10.44
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