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PERM1 regulates energy metabolism in the heart via ERRα/PGC−1α axis

AimsPERM1 is a striated muscle-specific regulator of mitochondrial bioenergetics. We previously demonstrated that PERM1 is downregulated in the failing heart and that PERM1 positively regulates metabolic genes known as targets of the transcription factor ERRα and its coactivator PGC-1α in cultured c...

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Principais autores: Shin-ichi Oka, Karthi Sreedevi, Thirupura S. Shankar, Shreya Yedla, Sumaita Arowa, Amina James, Kathryn G. Stone, Katia Olmos, Amira D. Sabry, Amanda Horiuchi, Keiko M. Cawley, Sean A. O’very, Mingming Tong, Jaemin Byun, Xiaoyong Xu, Sanchita Kashyap, Youssef Mourad, Omair Vehra, Dallen Calder, Ty Lunde, Tong Liu, Hong Li, J. Alan Mashchek, James Cox, Yukio Saijoh, Stavros G. Drakos, Junco S. Warren
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-11-01
Serier:Frontiers in Cardiovascular Medicine
Fag:
PERM1
heart
ERRα
metabolomics
proteomics
metabolism
Online adgang:https://www.frontiersin.org/articles/10.3389/fcvm.2022.1033457/full
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