Anti-Tumoral Effects of a (1<i>H</i>-Pyrrol-1-yl)Methyl-1<i>H</i>-Benzoimidazole Carbamate Ester Derivative on Head and Neck Squamous Carcinoma Cell Lines

Nocodazole is an antineoplastic agent that exerts its effects by depolymerizing microtubules. Herein we report a structural analog of nocodazole, a (1<i>H</i>-pyrrol-1-yl)methyl-1<i>H</i>-benzoimidazole carbamate ester derivative, named RDS 60. We evaluated the antineoplastic properties of RDS 60 in...

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Auteurs principaux:	Alice Nicolai, Valentina Noemi Madia, Antonella Messore, Daniela De Vita, Alessandro De Leo, Davide Ialongo, Valeria Tudino, Elisabetta Tortorella, Luigi Scipione, Samanta Taurone, Tiziano Pergolizzi, Marco Artico, Roberto Di Santo, Roberta Costi, Susanna Scarpa
Format:	Artigo
Langue:	Inglês
Publié:	MDPI AG 2021-06-01
Collection:	Pharmaceuticals
Sujets:	pyrroles benzimidazoles nocodazole head and neck squamous cell carcinoma apoptosis epithelial-mesenchymal transition
Accès en ligne:	https://www.mdpi.com/1424-8247/14/6/564
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