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Exploratory transcriptomic analysis of mouse articular cartilage in response to tissue inhibitor of metalloproteinase 3 identifies inflammation-associated gene expression changes

IntroductionTissue inhibitor of metalloproteinase 3 (TIMP-3) is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) and ADAM/ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family enzymes that regulate extracellular matrix (ECM) homeostasis. Because these enzymes p...

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Principais autores: Manuela Mengozzi, Ben Towler, Jordan Kwabiah, Fawad Razmandeh, Fabio Simoes, Lisa Mullen
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-03-01
coleção:Frontiers in Immunology
Assuntos:
cartilage
hypoxia
interleukin-17
lipocalin-2
osteoarthritis
serum amyloid A proteins
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1794078/full
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