EHMT2 promotes tumorigenesis in GNAQ/11-mutant uveal melanoma via ARHGAP29-mediated RhoA pathway

Constitutive activation of GNAQ/11 is the initiative oncogenic event in uveal melanoma (UM). Direct targeting GNAQ/11 has yet to be proven feasible as they are vital for a plethora of cellular functions. In search of genetic vulnerability for UM, we found that inhibition of euchromatic histone lysin...

Täydet tiedot

Bibliografiset tiedot

Päätekijät:	Yongyun Li, Tianyu Zhu, Jie Yang, Qianqian Zhang, Shiqiong Xu, Shengfang Ge, Renbing Jia, Jianming Zhang, Xianqun Fan
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	Elsevier 2024-03-01
Sarja:	Acta Pharmaceutica Sinica B
Aiheet:	Uveal melanoma EHMT2 RhoA pathway ARHGAP29 G protein GNAQ
Linkit:	http://www.sciencedirect.com/science/article/pii/S2211383523004707
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