An Efficacious Transgenic Strategy for Triple Knockout of Xeno-Reactive Antigen Genes GGTA1, CMAH, and B4GALNT2 from Jeju Native Pigs

Pigs are promising donors of biological materials for xenotransplantation; however, cell surface carbohydrate antigens, including galactose-alpha-1,3-galactose (α-Gal), N-glycolylneuraminic acid (Neu5Gc), and Sd blood group antigens, play a significant role in porcine xenograft rejection. Inactivati...

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Detalhes bibliográficos

Principais autores:	Seungwon Yoon, Seulgi Lee, Chungyu Park, Hyunyong Choi, Minwoo Yoo, Sang Chul Lee, Cheol-Ho Hyun, Nameun Kim, Taeyoung Kang, Eugene Son, Mrinmoy Ghosh, Young-Ok Son, Chang-Gi Hur
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2022-09-01
coleção:	Vaccines
Assuntos:	CRISPR-CAS9 system xenotransplantation immune rejection Jeju native pigs
Acesso em linha:	https://www.mdpi.com/2076-393X/10/9/1503
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