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Antigen Specificity and Clinical Significance of IgG and IgA Autoantibodies Produced in situ by Tumor-Infiltrating B Cells in Breast Cancer

An important role for tumor infiltrating B lymphocytes (TIL-B) in the immune response to cancer is emerging; however, very little is known about the antigen specificity of antibodies produced in situ. The presence of IgA antibodies in the tumor microenvironment has been noted although their biologic...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Soizic Garaud, Pawel Zayakin, Laurence Buisseret, Undine Rulle, Karina Silina, Alexandre de Wind, Gert Van den Eyden, Denis Larsimont, Karen Willard-Gallo, Aija Linē
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2018-11-01
Schriftenreihe:Frontiers in Immunology
Schlagworte:
tumor-infiltrating B cells
autoantibodies
IgG
IgA
tertiary lymphoid structures
breast cancer
Online-Zugang:https://www.frontiersin.org/article/10.3389/fimmu.2018.02660/full
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