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Safety and Tolerability of Nicotinamide Riboside in Heart Failure With Reduced Ejection Fraction

Summary: The mitochondrial dysfunction characteristic of heart failure (HF) is associated with changes in intracellular nicotinamide adenine dinucleotide (NAD+) and NADH levels. Raising NAD+ levels with the NAD+ precursor, nicotinamide riboside (NR), may represent a novel HF treatment. In this 30-pa...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Dennis D. Wang, MD, PhD, Sophia E. Airhart, MD, Bo Zhou, PhD, Laura M. Shireman, PhD, Siyi Jiang, BS, Carolina Melendez Rodriguez, MD, James N. Kirkpatrick, MD, Danny D. Shen, PhD, Rong Tian, MD, PhD, Kevin D. O’Brien, MD
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2022-12-01
Schriftenreihe:JACC: Basic to Translational Science
Schlagworte:
nicotinamide riboside
NR
nicotinamide adenine dinucleotide
NAD+
heart failure with reduced ejection fraction
HFrEF
Online-Zugang:http://www.sciencedirect.com/science/article/pii/S2452302X22002327
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