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Dynein–Dynactin–NuMA clusters generate cortical spindle-pulling forces as a multi-arm ensemble

To position the mitotic spindle within the cell, dynamic plus ends of astral microtubules are pulled by membrane-associated cortical force-generating machinery. However, in contrast to the chromosome-bound kinetochore structure, how the diffusion-prone cortical machinery is organized to generate lar...

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Principais autores: Masako Okumura, Toyoaki Natsume, Masato T Kanemaki, Tomomi Kiyomitsu
Format: Artigo
Jezik:Inglês
Izdano: eLife Sciences Publications Ltd 2018-05-01
Serija:eLife
Teme:
Online dostop:https://elifesciences.org/articles/36559
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