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Establishing elements of a synthetic biology platform for Vaccinia virus production: BioBrick™ design, serum-free virus production and microcarrier-based cultivation of CV-1 cells

Vaccinia virus (VACV) is an established vector for vaccination and is beginning to prove effective as an oncolytic agent. Industrial production of VACV stands to benefit in future from advances made by synthetic biology in genome engineering and standardisation. The CV-1 cell line can be used for VA...

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Autors principals: Shuchang Liu, Ludmila Ruban, Yaohe Wang, Yuhong Zhou, Darren N. Nesbeth
Format: Artigo
Idioma:Inglês
Publicat: Elsevier 2017-02-01
Col·lecció:Heliyon
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Accés en línia:http://www.sciencedirect.com/science/article/pii/S2405844016320151
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