A peripheral lipid sensor GPR120 remotely contributes to suppression of PGD2-microglia-provoked neuroinflammation and neurodegeneration in the mouse hippocampus

Abstract Background Neuroinflammation is a key pathological component of neurodegenerative disease and is characterized by microglial activation and the secretion of proinflammatory mediators. We previously reported that a surge in prostaglandin D2 (PGD2) production and PGD2-induced microglial activ...

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Detalhes bibliográficos

Principais autores:	Kensuke Iwasa, Shinji Yamamoto, Kota Yamashina, Nan Yagishita-kyo, Kei Maruyama, Takeo Awaji, Yoshinori Takei, Akira Hirasawa, Keisuke Yoshikawa
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2021-12-01
coleção:	Journal of Neuroinflammation
Assuntos:	Prostaglandin G-protein-coupled receptor 120 (GPR120) Neuroinflammation
Acesso em linha:	https://doi.org/10.1186/s12974-021-02361-2
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