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A gut-oral microbiome–driven axis controls oropharyngeal candidiasis through retinoic acid

A side effect of antibiotics is outgrowth of the opportunistic fungus Candida albicans in the oropharynx (oropharyngeal candidiasis, OPC). IL-17 signaling is vital for immunity to OPC, but how the microbiome impacts antifungal immunity is not well understood. Mice in standard specific pathogen–free...

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Autors principals: Felix E.Y. Aggor, Martinna Bertolini, Chunsheng Zhou, Tiffany C. Taylor, Darryl A. Abbott, Javonn Musgrove, Vincent M. Bruno, Timothy W. Hand, Sarah L. Gaffen
Format: Artigo
Idioma:Inglês
Publicat: American Society for Clinical investigation 2022-09-01
Col·lecció:JCI Insight
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Accés en línia:https://doi.org/10.1172/jci.insight.160348
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