AMPKα2 promotes tumor immune escape by inducing CD8+ T-cell exhaustion and CD4+ Treg cell formation in liver hepatocellular carcinoma

Abstract Background Adenosine monophosphate-activated protein kinase (AMPK) is associated with the development of liver hepatocellular carcinoma (LIHC). AMPKα2, an α2 subunit of AMPK, is encoded by PRKAA2, and functions as the catalytic core of AMPK. However, the role of AMPKα2 in the LIHC tumor imm...

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Hauptverfasser:	Yan Ouyang, Yan Gu, Xinhai Zhang, Ya Huang, Xianpeng Wei, Fuzhou Tang, Shichao Zhang
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	BMC 2024-03-01
Schriftenreihe:	BMC Cancer
Schlagworte:	AMPKα2 Cell communication CD8+ T-cell exhaustion Tumor immune escape Immunotherapy Liver hepatocellular carcinoma
Online-Zugang:	https://doi.org/10.1186/s12885-024-12025-y
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