Deletion of ribosomal protein genes is a common vulnerability in human cancer, especially in concert with TP53 mutations

Abstract Heterozygous inactivating mutations in ribosomal protein genes (RPGs) are associated with hematopoietic and developmental abnormalities, activation of p53, and altered risk of cancer in humans and model organisms. Here we performed a large‐scale analysis of cancer genome data to examine the...

תיאור מלא

מידע ביבליוגרפי

Principais autores:	Ram Ajore, David Raiser, Marie McConkey, Magnus Jöud, Bernd Boidol, Brenton Mar, Gordon Saksena, David M Weinstock, Scott Armstrong, Steven R Ellis, Benjamin L Ebert, Björn Nilsson
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	Springer Nature 2017-03-01
סדרה:	EMBO Molecular Medicine
נושאים:	cancer ribosomal gene haploinsufficiency ribosome function
גישה מקוונת:	https://doi.org/10.15252/emmm.201606660
תגים:	הוספת תג אין תגיות, היה/י הראשונ/ה לתייג את הרשומה!