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Identification of internalizing ScFvs for EGFR inhibition and apoptosis induction in cholangiocarcinoma cells

Abstract Cholangiocarcinoma (CCA) is an aggressive malignancy with limited treatment options. EGFR overexpression is associated with tumor recurrence and poor prognosis, yet current EGFR-targeted therapies show limited efficacy. To identify alternative therapeutic candidates, we performed subtractiv...

Deskribapen osoa

Gorde:
Egile Nagusiak: Apinya Sayinta, Jinchutha Duangdara, Thitima Sumphanapai, Kuntalee Rangnoi, Boonyakorn Boonsri, Kittiya Supradit, Nopporn Jongkamonwiwat, Kiattawee Choowongkomon, Veerachai Thitapakorn, Montarop Yamabhai, Kanokpan Wongprasert
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Portfolio 2025-11-01
Saila:Scientific Reports
Gaiak:
Cholangiocarcinoma
Single-chain variable fragment (scFv)
EGFR tyrosine kinase
Antibodies internalization
Apoptosis
Sarrera elektronikoa:https://doi.org/10.1038/s41598-025-24324-w
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