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The contribution of Lynch syndrome to early onset malignancy in Ireland

Abstract Background Lynch syndrome (LS) is an autosomal dominant hereditary cancer syndrome responsible for 2–4% of hereditary colorectal cancers (CRC). Mismatch repair protein deficiency (dMMR) is a characteristic feature of LS. It has been associated with a poor response to standard chemotherapy i...

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Principais autores: Alice Talbot, Emily O’Donovan, Eileen Berkley, Carmel Nolan, Roisin Clarke, David Gallagher
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2021-05-01
סדרה:BMC Cancer
נושאים:
Lynch syndrome
Colorectal Cancer
DNA mismatch repair (MMR)
Database
Microsatellite instability (MSI)
גישה מקוונת:https://doi.org/10.1186/s12885-021-08263-z
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