MOF-mediated acetylation of SIRT6 disrupts SIRT6-FOXA2 interaction and represses SIRT6 tumor-suppressive function by upregulating ZEB2 in NSCLC

Summary: Mammalian sirtuin 6 (SIRT6) regulates a spectrum of vital biological processes and has long been implicated in the progression of cancer. However, the mechanisms underlying the regulation of SIRT6 in tumorigenesis remain elusive. Here, we report that the tumor-suppressive function of SIRT6...

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Detalhes bibliográficos

Principais autores:	Kaiqiang Zhao, Mingyue Zheng, Zezhuo Su, Shrestha Ghosh, Chao Zhang, Wenzhao Zhong, Joshua Wing Kei Ho, Guoxiang Jin, Zhongjun Zhou
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2023-08-01
coleção:	Cell Reports
Assuntos:	CP: Cancer CP: Molecular biology
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2211124723009506
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