T cell intrinsic STAT1 signaling prevents aberrant Th1 responses during acute toxoplasmosis

Infection-induced T cell responses must be properly tempered and terminated to prevent immuno-pathology. Using transgenic mice, we demonstrate that T cell intrinsic STAT1 signaling is required to curb inflammation during acute infection with Toxoplasma gondii. Specifically, we report that mice lacki...

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Xehetasun bibliografikoak

Egile Nagusiak:	Aaron B. Schultz, David G. Kugler, Luis Nivelo, Nicolas Vitari, Laura P. Doyle, Svetlana Ristin, Lothar Hennighausen, John J. O’Shea, Dragana Jankovic, Alejandro V. Villarino
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2023-07-01
Saila:	Frontiers in Immunology
Gaiak:	JAK - STAT signaling pathway cytokine STAT1 STAT3 IL-27 (interleukin 27) IL-10 (interleukin 10)
Sarrera elektronikoa:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1212190/full
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