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Neoadjuvant fuzuloparib combined with abiraterone for localized high-risk prostate cancer (FAST-PC): A single-arm phase 2 study

Summary: Preclinical studies suggest synergistic effects between androgen receptor inhibitors and poly(adenosine diphosphate-ribose) polymerase (PARP) inhibitors. This phase 2 trial (NCT05223582) evaluates neoadjuvant fuzuloparib plus abiraterone in 35 treatment-naive men with localized high-risk pr...

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Principais autores: Tingwei Zhang, Beihe Wang, Yu Wei, Hualei Gan, Bangwei Fang, Xiaomeng Li, Junlong Wu, Xiaojie Bian, Jianfei Wang, Stephen J. Freedland, Shenglin Huang, Dingwei Ye, Yao Zhu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-03-01
Serier:Cell Reports Medicine
Fag:
Prostate cancer
neoadjuvant
fuzuloparib
abiraterone
Online adgang:http://www.sciencedirect.com/science/article/pii/S2666379125000916
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