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Metformin is a metabolic modulator and radiosensitiser in rectal cancer

Resistance to neoadjuvant chemoradiation therapy, is a major challenge in the management of rectal cancer. Increasing evidence supports a role for altered energy metabolism in the resistance of tumours to anti-cancer therapy, suggesting that targeting tumour metabolism may have potential as a novel...

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Furkejuvvon:
Váldodahkkit: Croí E. Buckley, Rebecca M. O’Brien, Timothy S. Nugent, Noel E. Donlon, Fiona O’Connell, John V. Reynolds, Adnan Hafeez, Diarmuid S. O’Ríordáin, Robert A. Hannon, Paul Neary, Reza Kalbassi, Brian J. Mehigan, Paul H. McCormick, Cara Dunne, Michael E. Kelly, John O. Larkin, Jacintha O’Sullivan, Niamh Lynam-Lennon
Materiálatiipa: Artigo
Giella:Inglês
Almmustuhtton: Frontiers Media S.A. 2023-08-01
Ráidu:Frontiers in Oncology
Fáttát:
metformin
rectal cancer
colorectal
radiosensitiser
energy metabolism
radioresistance
Liŋkkat:https://www.frontiersin.org/articles/10.3389/fonc.2023.1216911/full
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