Targeting glioblastoma with HDAC inhibitors: insights into hydroxamic acid-based therapeutic strategies

Abstract Epigenetic modifications play crucial roles in glioblastoma growth and aggressiveness, with key regulators including histone deacetylases (HDACs), histone acetyltransferases (HATs), and methyltransferases. Targeting these epigenetic alterations has emerged as a promising therapeutic strateg...

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Autori principali:	Padmini Pai, Ipshita Das, Yashaswini Reddy, Babu Santhi Venkidesh, Poonam Bhandari, Manjunath Madalageri, Veeresh Sadashivanavar, Karkala Sreedhara Ranganath Pai, Pallavi Rao, Srinivas Oruganti, Manasa Gangadhar Shetty, Kapaettu Satyamoorthy, Babitha Kampa Sundara
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	BMC 2025-12-01
Serie:	Acta Neuropathologica Communications
Soggetti:	Anticancer Glioblastoma Histone deacetylase Hydroxamic acid Isoform selective
Accesso online:	https://doi.org/10.1186/s40478-025-02194-7
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