High Glucose Induced Changes in Human VEC Phenotype in a 3D Hydrogel Derived From Cell-Free Native Aortic Root

Background: Valvular endothelial cells (VEC) have key roles in maintaining valvular integrity and homeostasis, and dysfunctional VEC are the initiators and major contributors to aortic valve disease in diabetes. Previous studies have shown that HG stimulated an inflammatory phenotype in VEC. Inflamm...

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Detalhes bibliográficos

Principais autores:	Sergiu Cecoltan, Letitia Ciortan, Razvan D. Macarie, Mihaela Vadana, Andreea C. Mihaila, Monica Tucureanu, Mihaela-Loredana Vlad, Ionel Droc, Mihaela Gherghiceanu, Agneta Simionescu, Dan Teodor Simionescu, Elena Butoi, Ileana Manduteanu
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2021-08-01
coleção:	Frontiers in Cardiovascular Medicine
Assuntos:	3D-valve model endothelin-1 endothelial to mesenchymal transition high glucose inflammation valvular endothelial cells
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcvm.2021.714573/full
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