Akt inhibitor augments anti-proliferative efficacy of a dual mTORC1/2 inhibitor by FOXO3a activation in p53 mutated hepatocarcinoma cells

Abstract Hepatocellular carcinoma (HCC) is one of the most common malignancy-related deaths. p53 mutation in HCC associates with worse clinicopathologic features including therapeutic limitation. A combination of targeted therapy may have some advantages. Akt/mTOR signaling contributes to the regula...

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Bibliografische Detailangaben

Hauptverfasser:	Tapas Patra, Keith Meyer, Ratna B. Ray, Tatsuo Kanda, Ranjit Ray
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Publishing Group 2021-11-01
Schriftenreihe:	Cell Death and Disease
Online-Zugang:	https://doi.org/10.1038/s41419-021-04371-7
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