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Tumor Treating Fields (TTFields) induce homologous recombination deficiency in ovarian cancer cells, thus mitigating drug resistance

BackgroundOvarian cancer is the leading cause of mortality among gynecological malignancies. Carboplatin and poly (ADP-ribose) polymerase inhibitors (PARPi) are often implemented in the treatment of ovarian cancer. Homologous recombination deficient (HRD) tumors demonstrate increased sensitivity to...

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Principais autores: Yani Berckmans, Hila M. Ene, Kerem Ben-Meir, Antonia Martinez-Conde, Roxanne Wouters, Bieke Van den Ende, Sara Van Mechelen, Roni Monin, Roni Frechtel-Gerzi, Hila Gabay, Eyal Dor-On, Adi Haber, Uri Weinberg, Ignace Vergote, Moshe Giladi, An Coosemans, Yoram Palti
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2024-06-01
Serier:Frontiers in Oncology
Fag:
Tumor Treating Fields (TTFields)
ovarian cancer
drug resistance
DNA damage
synthetic lethality
conditional vulnerability
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2024.1402851/full
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