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Heterologous redox partners supporting the efficient catalysis of epothilone B biosynthesis by EpoK in Schlegelella brevitalea

Abstract Background Epothilone B is a natural product that stabilizes microtubules, similar to paclitaxel (Taxol); therefore, epothilone B and several derivatives have shown obvious antitumour activities. Some of these products are in clinical trials, and one (ixabepilone, BMS) is already on the mar...

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Principais autores: Junheng Liang, Huimin Wang, Xiaoying Bian, Youming Zhang, Guoping Zhao, Xiaoming Ding
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2020-09-01
סדרה:Microbial Cell Factories
נושאים:
Epothilone B
EpoK (CYP167A1)
Electron transport partner
Gene overexpression
Whole-cell biotransformation
גישה מקוונת:http://link.springer.com/article/10.1186/s12934-020-01439-5
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