Enhanced in vivo blood brain barrier transcytosis of macromolecular cargo using an engineered pH-sensitive mouse transferrin receptor binding nanobody

Abstract Background The blood brain barrier limits entry of macromolecular diagnostic and therapeutic cargos. Blood brain barrier transcytosis via receptor mediated transport systems, such as the transferrin receptor, can be used to carry macromolecular cargos with variable efficiency. Transcytosis...

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Bibliografiset tiedot

Päätekijät:	Thomas J. Esparza, Shiran Su, Caroline M. Francescutti, Elvira Rodionova, Joong Hee Kim, David L. Brody
Aineistotyyppi:	Artigo
Kieli:	Inglês
Julkaistu:	BMC 2023-08-01
Sarja:	Fluids and Barriers of the CNS
Aiheet:	Blood brain barrier Transferrin receptor Nanobody Neurotensin Histidine P2X7 receptor
Linkit:	https://doi.org/10.1186/s12987-023-00462-z
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