Large-scale molecular endotype discovery in synovial fluid reveals osteoarthritis as a single biological continuum

Abstract Knee osteoarthritis affects 40% of people during their lifetime, significantly impacting societies worldwide. Its molecular pathogenesis remains poorly understood and variable clinical phenotypes suggest it may be more than one disease. We established Synovial fluid To detect Endotypes by U...

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Autori principali:	T. A. Perry, Y. Deng, P. A. Hulley, R. A. Maciewicz, J. Mitchelmore, S. Larsson, J. Gogain, S. Brachat, A. Struglics, C. T. Appleton, S. Kluzek, N. K. Arden, D. Felson, L. Bondi, M. Kapoor, L. S. Lohmander, T. J. Welting, D. A. Walsh, A. M. Valdes, Luke Jostins-Dean, Fiona E. Watt, B. D. M. Tom, T. L. Vincent, On behalf of the STEpUP OA Consortium
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Nature Portfolio 2026-06-01
Serie:	Nature Communications
Accesso online:	https://doi.org/10.1038/s41467-026-71632-4
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