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A critical role of Pax6 in alcohol-induced fetal microcephaly

Maternal alcohol abuse during pregnancy is one of the leading causes of birth defects in humans. Despite extensive studies, the molecular basis is still not clear. Here we transiently exposed Xenopus embryos to alcohol and showed that alcohol dose-dependently produced microcephaly and growth retarda...

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Principais autores: Ying Peng, Pai-Hao Yang, Samuel S.M Ng, Oscar G Wong, Jie Liu, Ming-Liang He, Hsiang-Fu Kung, Marie C.M Lin
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2004-07-01
Serier:Neurobiology of Disease
Fag:
Fetal alcohol syndrome
Microcephaly
Pax6
Reactive oxygen species
Online adgang:http://www.sciencedirect.com/science/article/pii/S0969996104000622
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