CHFR expression and sensitivity of breast cancer cells to antimitotic agents in vitro and in the I-SPY trial

Abstract CHFR, which encodes an E3 ubiquitin ligase previously implicated in regulating the premitotic checkpoint and response to taxanes, is silenced in a subset of breast cancers. Here we assessed the impact of differences in CHFR expression on sensitivity to various antimitotic agents in vitro an...

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Principais autores:	Andrea E. Wahner Hendrickson, Karen S. Flatten, Taylor M. Weiskittel, Annapoorna Venkatachalam, Annabella R. Strathman, Olivia K. Rossman, X. Wei Meng, Paula A. Schneider, Kevin L. Peterson, Cristina Correia, Olivia J. Anderson, Saloni Singh, Fergus J. Couch, Laura J. Esserman, Nola M. Hylton, Natsuko Onishi, Angela M. DeMichele, Junjie Chen, Hu Li, James N. Ingle, Matthew P. Goetz, Scott H. Kaufmann
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2025-10-01
coleção:	npj Breast Cancer
Acesso em linha:	https://doi.org/10.1038/s41523-025-00830-y
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