Exploring the causal association between epigenetic clocks and menopause age: insights from a bidirectional Mendelian randomization study

BackgroundEvidence suggests a connection between DNA methylation (DNAm) aging and reproductive aging. However, the causal relationship between DNAm and age at menopause remains uncertain.MethodsEmploying established DNAm epigenetic clocks, such as DNAm Hannum age acceleration (Hannum), Intrinsic epi...

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Autori principali:	Ling Wang, Shuling Xu, Rumeng Chen, Yining Ding, Menghua Liu, Chunyan Hou, Zhu Wu, Xiaoju Men, Meihua Bao, Binsheng He, Sen Li
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2024-08-01
Serie:	Frontiers in Endocrinology
Soggetti:	epigenetic clocks DNA methylation menopause Mendelian randomization causal association
Accesso online:	https://www.frontiersin.org/articles/10.3389/fendo.2024.1429514/full
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