A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC50 value of 1.57 µM against acet...

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Bibliografische Detailangaben

Hauptverfasser:	Abdulrahman I. Almansour, Raju Suresh Kumar, Natarajan Arumugam, Alireza Basiri, Yalda Kia, Mohamed Ashraf Ali, Mehvish Farooq, Vikneswaran Murugaiyah
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2015-01-01
Schriftenreihe:	Molecules
Schlagworte:	acetylcholinesterase (AChE), butyrylcholinesterase (BChE), Alzheimer’s disease (AD), spiropyrrolidines, ionic liquid and molecular docking study
Online-Zugang:	http://www.mdpi.com/1420-3049/20/2/2296
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