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Antigen-driven T cell-macrophage interactions mediate the interface between innate and adaptive immunity in histidyl-tRNA synthetase-induced myositis

IntroductionPrevious work in humans has demonstrated that both innate and adaptive immune signaling pathways contribute to the pathogenesis of idiopathic inflammatory myopathy (IIM), a systemic autoimmune disease targeting muscle as well as extra-muscular organs. To better define interactive signali...

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Principais autores: Daniel P. Reay, Tracy Tabib, Ying Wang, Timothy B. Oriss, Nicholas A. Young, Robert A. Lafyatis, Wael N. Jarjour, Paula R. Clemens, Dana P. Ascherman
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2023-09-01
Serier:Frontiers in Immunology
Fag:
myositis
HRS (histidyl-tRNA synthetase)
T cell
macrophage
innate immunity
adaptive immunity
Online adgang:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1238221/full
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