Aspartoacylase-lacZ knockin mice: an engineered model of Canavan disease.

Canavan Disease (CD) is a recessive leukodystrophy caused by loss of function mutations in the gene encoding aspartoacylase (ASPA), an oligodendrocyte-enriched enzyme that hydrolyses N-acetylaspartate (NAA) to acetate and aspartate. The neurological phenotypes of different rodent models of CD vary c...

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Principais autores:	Nadine Mersmann, Dmitri Tkachev, Ruth Jelinek, Philipp Thomas Röth, Wiebke Möbius, Torben Ruhwedel, Sabine Rühle, Wolfgang Weber-Fahr, Alexander Sartorius, Matthias Klugmann
Format:	Artigo
Jezik:	Inglês
Izdano:	Public Library of Science (PLoS) 2011-01-01
Serija:	PLoS ONE
Online dostop:	http://europepmc.org/articles/PMC3098885?pdf=render
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