Fibronectin and vitronectin alleviate adipose-derived stem cells senescence during long-term culture through the AKT/MDM2/P53 pathway

Abstract Cellular senescence plays a role in the development of aging-associated degenerative diseases. Cell therapy is recognized as a candidate treatment for degenerative diseases. To achieve the goal of cell therapy, the quality and good characteristics of cells are concerned. Cell expansion reli...

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Bibliografische Detailangaben

Hauptverfasser:	Patcharapa Tragoonlugkana, Chatchai Pruksapong, Pawared Ontong, Witchayapon Kamprom, Aungkura Supokawej
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Nature Portfolio 2024-06-01
Schriftenreihe:	Scientific Reports
Schlagworte:	Adipose-derived stem cells Cell therapy Good manufacturing practice Cell culture Replicative senescence Fibronectin
Online-Zugang:	https://doi.org/10.1038/s41598-024-65339-z
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