Indole-3-carboxaldehyde from Limosilactobacillus reuteri targets the DUSP1/ERK/NOX2/ROS axis to enhance the bactericidal activity of macrophages and protects against sepsis

The gut microbiota plays a critical regulatory role in the pathogenesis of sepsis, yet the immunomodulatory mechanisms of Limosilactobacillus reuteri (L. reuteri) and its metabolites in sepsis remain to be fully elucidated. This study found that the abundance of intestinal L. reuteri was significant...

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Detalhes bibliográficos

Principais autores:	Zhiwang Li, Peiyu Li, Tian Peng, Xing Zhou, Yihong Liu, Chenmu Ai, Neng Xiao, Shunxin Song, Xiaomei Lei, Junyong Liu, Wenlei Wang, Pan Zhou, Zhangyong Li, Zhanhong Liu, Xingui Dai, Zhiming Zhang, Tao Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Taylor & Francis Group 2026-12-01
coleção:	Gut Microbes
Assuntos:	Sepsis Limosilactobacillus reuteri indole-3-carboxaldehyde DUSP1 macrophage phagocytosis
Acesso em linha:	https://www.tandfonline.com/doi/10.1080/19490976.2026.2671382
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