Induction of Oxidative Stress and Ferroptosis in Triple-Negative Breast Cancer Cells by Niclosamide via Blockade of the Function and Expression of SLC38A5 and SLC7A11

The amino acid transporters SLC38A5 and SLC7A11 are upregulated in triple-negative breast cancer (TNBC). SLC38A5 transports glutamine, methionine, glycine and serine, and therefore activates mTOR signaling and induces epigenetic modifications. SLC7A11 transports cystine and increases the cellular le...

पूर्ण विवरण

ग्रंथसूची विवरण

मुख्य लेखकों:	Marilyn Mathew, Sathish Sivaprakasam, Gunadharini Dharmalingam-Nandagopal, Souad R. Sennoune, Nhi T. Nguyen, Valeria Jaramillo-Martinez, Yangzom D. Bhutia, Vadivel Ganapathy
स्वरूप:	Artigo
भाषा:	Inglês
प्रकाशित:	MDPI AG 2024-02-01
श्रृंखला:	Antioxidants
विषय:	SLC38A5 SLC7A11 TNBC cells seleno-methionine glutathione glutathione peroxidase
ऑनलाइन पहुंच:	https://www.mdpi.com/2076-3921/13/3/291
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