In-silico studies, synthesis, and pharmacological screening of novel multitarget diphenylpyrazole scaffold as EGFR/BRAF and cyclooxygenase-2 inhibitors

Abstract Multi-targeting drug design has become a prevalent attitude in exploring effective potent anticancer agents. In this regard, cyclooxygenase II (COX 2), tubulin, and focal adhesion kinase (FAK) are emerging as highly effective targets in the battle against cancer. Pyrazoles AS-(1–16) were pr...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής

Κύριοι συγγραφείς:	Mohamed A. Abdelgawad, Syed N. A. Bukhari, Mohammed H. Elkomy, Mohammed Elmowafy, Ehab M. Mostafa, Arafa Musa, Waqas Ahmad, Mohamed Sadek Abdel-Bakky, Amr Farouk, Heba A. H. Elshemy, Asmaa G. Safi El-Din
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Nature Portfolio 2025-12-01
Σειρά:	Scientific Reports
Θέματα:	Breast cancer Neoplasm Biological marker Pyrazoles Docking EGFR
Διαθέσιμο Online:	https://doi.org/10.1038/s41598-025-33006-6
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