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Global DNA hypomethylation of Alu and LINE-1 transposable elements as an epigenetic biomarker of anti-tuberculosis drug-induced liver injury

Despite being highly effective, anti-tuberculosis (TB) drugs often induce adverse liver injury, anti-TB drug-induced liver injury (ATDILI), leading to treatment failure given no sensitive and selective ATDILI markers. Herein, we conducted a case–control association study to determine whether global...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Wanvisa Udomsinprasert, Wanchaloem Sakuntasri, Jiraphun Jittikoon, Usa Chaikledkaew, Sittisak Honsawek, Wasun Chantratita, Sukanya Wattanapokayakit, Surakameth Mahasirimongkol
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis Group 2021-01-01
Schriftenreihe:Emerging Microbes and Infections
Schlagworte:
Alu
LINE-1
global DNA methylation
anti-tuberculosis drug-induced liver injury
tuberculosis
biomarker
Online-Zugang:https://www.tandfonline.com/doi/10.1080/22221751.2021.1976079
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